Fisetin
Promotes Stem Cell Renewal and Longevity
Fisetin is a natural plant compound found in foods like strawberries, apples, onions, and cucumbers. It acts as a powerful antioxidant and anti-inflammatory, protecting the body’s cells from damage caused by stress and aging. Scientists have discovered that fisetin can help the body remove old, “senescent” cells—cells that stop working properly and cause inflammation as we age. By clearing these cells, fisetin helps tissues stay healthier for longer. It also supports brain and memory function, keeps the mitochondria (the cell’s energy centers) working well, and may help protect against age-related diseases like Alzheimer’s. Because of these effects, fisetin is being studied as a natural compound that could slow aging and support long-term vitality.
Health Benefits of Fisetin
Fisetin offers significant benefits to stem cells, particularly in supporting their health, renewal, and function as we age. Stem cells are responsible for repairing and regenerating tissues, but over time they become damaged or less active due to oxidative stress, inflammation, and cellular aging (senescence). Fisetin helps protect stem cells by acting as a strong antioxidant, reducing free radical damage, and lowering inflammation in their environment. It also works as a senolytic compound, helping remove old, dysfunctional cells that release harmful signals and interfere with stem cell regeneration. This creates a healthier cellular environment that allows stem cells to divide, repair, and restore tissues more effectively. In animal and lab studies, fisetin has been shown to extend stem cell lifespan, improve their ability to differentiate into new cells, and maintain tissue vitality—making it a promising compound for regenerative medicine and longevity research.
How Fisetin play a role in antiaging process?
By clearing out these senescent cells, fisetin supports healthier cell turnover, tissue repair, and organ function.
Studies show fisetin activates cellular pathways such as Nrf2 and AMPK, which enhance energy metabolism and detoxification.
These pathways help stem cells self-renew (make more of themselves) and differentiate properly into new tissue cells.
Over time, this helps maintain or even restore stem cell numbers in aging tissues.
It also activates longevity pathways, such as the Nrf2 antioxidant system, which protects DNA and mitochondria from damage, and the AMPK pathway, which helps regulate metabolism and energy balance. Studies in animals show that fisetin can extend lifespan, improve cognitive function, enhance skin health, and maintain youthful energy levels by keeping cells younger and more functional. In short, fisetin promotes healthspan—the number of years you live in good health—by protecting cells, reducing inflammation, and supporting natural cellular renewal throughout the body.
DISCLAIMER:
At Lumiage, our mission is to educate about the potential of stem cells and their vital role in the body’s natural repair system. The information shared on this website—including articles, educational materials, videos, testimonials, and other content—is intended solely for informational and educational purposes.
Our core belief is simple: Lumiage® supports the body’s natural renewal process by promoting an increase in circulating stem cells. We invite you to ask yourself, “What could be possible if your body had more active stem cells in circulation?”
Our products are supported by scientific research, and the increase in circulating stem cells is documented through clinical trials and ongoing studies. We reference peer-reviewed research to illustrate the broader, science-based effects of stem cells within the body. All research cited is derived from studies conducted by Lumiage and/or independent laboratories to ensure scientific integrity and reliability.
Please note that the information provided does not constitute medical advice and should not be used to diagnose, treat, or prevent any medical condition. Individual results may vary, and the testimonials or experiences shared are personal to each individual. Always consult your healthcare professional before starting any new supplement or wellness regimen.
These statements have not been evaluated by the U.S. Food and Drug Administration (FDA). Lumiage® products are not intended to diagnose, treat, cure, or prevent any disease
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Cracking the Stem Cell Code
“Our approach harnesses advanced stem cell science to naturally support the body’s repair and regeneration processes. By promoting circulating stem cells, these supplements enhance vitality, improve wellness, and help maintain optimal health, empowering individuals to live with energy, resilience, and overall life-long vitality at any age.”